News Summary

• People in Tübingen's type 2 diabetes risk cluster 5 continued to experience rising blood sugar, a sharp decline in insulin production, and a consistently elevated risk of developing diabetes.
• These unfavorable changes occurred even among people who lost a substantial amount of weight and maintained that loss for years.
• The results suggest that insulin resistance played a major role.
• Fatty liver disease and insulin resistance are the main disease processes affecting people in cluster 5.
• People with high-risk biological profiles such as cluster 5 may require more intensive care or treatments designed to address their specific metabolic problems.