News Summary

• Large language models (LLMs) show great potential for clinical decision-making.
• Most applications remain narrow, task-specific chat tools rather than systems integrated into clinical workflows.
• Building physician copilots will require models that operate within the electronic health record.
• MIRA (Medical Intelligence for Reasoning and Action) outperformed physicians in diagnostic accuracy and made guideline-concordant, medication-safe and appropriate admission decisions.
• Further work is needed to establish generalization, safety and governance through prospective, real-world studies.