News Summary

• Brain’s structural and functional connectomes (SC and FC) offer insights into the relationship between brain circuits and cognitive functioning in people with multiple sclerosis.
• diffusion and functional MRI, which are used to extract SC and FC, is expensive and time consuming, therefore are not currently used in the clinical setting.
• In this study, we identify the eSC and eFC brain circuits that are associated with baseline and 4-year follow-up cognition and assess their ability to predict cognition in MS.