News Summary

• Virus’s genome is a circular single-stranded DNA that features 5,386 nucleotides and encodes 11 proteins.
• Half of the single-nucleotide mutations, and 60% of those altering amino acids, were harmful to the phage.
• Cutting-edge AI systems for biology research that have shown promise in identifying harmful mutations struggled to predict the effects of the changes.
• The findings underscore the need for more, and better, experimental data to power these biological-AI tools.