Discovery and design of potent cell surface display elements
News Source : Nature.com
News Summary
- DeepSCan is a suite of deep learning and artificial intelligence models to reliably capture potent elements’ conserved features.
- We train three generations of DeepSCan models and evaluate their performance.
- 7 generative CSDs match or exceed the cell surface translocation strength of the most potent naturally occurring CSDs.
- Enhanced surface displays are validated across multiple cell types and are functional in an antigen-specific CAR-T cytotoxicity assay.
- All primary data supporting the findings of this study are available within the Article and via Zenodo.
Overington, J. P., AlLazikani, B. & Hopkins, A. L. How many drug targets are there? Nat. Rev. Drug Discov.5, 993996 (2006). Article CAS PubMed Google Scholar Hegde, R. S.
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